Newsgroups: alt.drugs Subject: Medline info on drug-drug interactions From: [lamon t g] at [cs.washington.edu] (Lamont Granquist) Date: Mon, 25 Oct 93 20:51:33 GMT ---------------------------------------------------------------------- On drug-drug interactions: Accession Number: 93000357. Citation: 2 of 4 Author: Strassman-R-J. Title: Human hallucinogen interactions with drugs affecting serotonergic neurotransmission. Source: Neuropsychopharmacology. 1992 Nov. 7(3). P 241-3. Abstract: The absence of relevant human research studies of hallucinogenic drugs has not curtailed their unsupervised use. Two cases are presented that suggest decreased sensitivity to the serotonergic hallucinogens psilocybin and LSD induced by drugs with effects on serotonergic neurotransmission, allopurinol and fluoxetine. These reports suggest that hallucinogens' effects in humans are mediated by serotonergic receptors. Accession Number: 92272338. Citation: 3 of 4 Author: Picker-W. Lerman-A. Hajal-F. Title: Potential interaction of LSD and fluoxetine [letter] Source: Am-J-Psychiatry. 1992 Jun. 149(6). P 843-4. Accession Number: 93359556. Citation: 1 of 45 Author: McCann-U-D. Ricaurte-G-A. Title: Reinforcing subjective effects of (+/-) 3,4-methylenedioxymethamphetamine ("ecstasy") may be separable from its neurotoxic actions: clinical evidence. Source: J-Clin-Psychopharmacol. 1993 Jun. 13(3). P 214-7. Abstract: (+/-)3,4-Methylenedioxymethamphetamine (MDMA), a synthetic amphetamine derivative used recreationally by humans, damages brain serotonin neurons in experimental animals. In preclinical studies, serotonin reuptake inhibitors block MDMA-induced serotonin release; they also block MDMA neurotoxicity. Whether serotonin reuptake inhibitors also block MDMA's psychoactive effects in humans has not been established. Reported herein are four individuals who describe their experiences after ingesting fluoxetine, a potent and selective serotonin reuptake inhibitor, before MDMA ingestion. Their reports indicate that fluoxetine does not block MDMA's reinforcing subjective effects and raise the possibility that MDMA's psychoactive effects may be separable from its neurotoxic actions.